Asociación genotípica y fenotípica del polimorfismo rs8192675 del transportador SLC2A2 con la hemoglobina glicosilada en pacientes con diabetes mellitus tipo 2 de la fundación DONUM

Abstract

Abstract: Diabetes mellitus is a disease with a diverse etiology where the genetic polymorphism play an important role. The current study encompasses a non-experimental cross-sectional study involving 102 individuals. The aim of the study was to carry out the genotypic and phenotypic association the rs8192675 polymorphism of the SLC2A2 gene with the glycosylated hemoglobin and its relationship with metabolic decompensation in patients with type 2 diabetes mellitus of the DONUM Foundation. The value of glycosylated hemoglobin was determined, and real time PCR technique was used for the polymorphism detection. The statistical analysis was performed with 95% confidence level and p≤0.05. The polymorphism presence was found in four patients of the researched population and a genotypic and allelic frequency of 4% (n=4 and n=8 respectively). The results claim that there is not statistically significant relationship between the genetic variant presence and glycosylated hemoglobin levels. Additionally, the polymorphism association with the compensation and decompensation status of patients determined that there is not significant association between both parameters. Finally, the polymorphism did not prove to be a risk or protection factor.