Instability of microsatellites in colo-rectal cancer and its distribution according to prognostic factors in SOLCA Cuenca 2004-2014.

Authors

  • Magdali del Rocío Murillo Bacilio Sociedad de lucha contra el cáncer SOLCA - Facultad de Ciencias Médicas Universidad de Cuenca https://orcid.org/0000-0002-9752-9722
  • Araceli Miroslava Palta Gonzalez Sociedad de lucha contra el cáncer - Facultad de Medicina de la Universidad del Azuay https://orcid.org/0000-0003-0103-8978
  • Fabián Gerardo Correa Martínez Hospital Municipal de la mujer y el niño - Facultad de Medicina Universidad Católica de Cuenca https://orcid.org/0000-0002-4007-2688
  • María Isabel León Pesantez Sociedad de lucha contra el cáncer SOLCA - Facultad de Medicina de la Universidad Católica de Cuenca https://orcid.org/0000-0003-0901-7768
  • Gabriela Elizabeth Patiño Murillo Estudiante de Medicina de la Universidad Católica de Cuenca https://orcid.org/0000-0003-3328-900X

Abstract

Abstract

Worldwide, colorectal cancer is the third most common neoplasm in men and the second in women. Tumorigenesis pathways allow us to sub-classify patients and protocolize treatments. The microsatellite instability constitutes one of these pathways; it is present in a 15% to 20% in colorectal carcinoma; its presence is associated with a better prognosis.

Objective:

To determine the frequency of microsatellite instability and its distribution according to prognostic factors in biopsies of patients with colorectal cancer in the Solca-Cuenca Cancer Institute during the period 2004-2014.

Method:

It is an observational, analytical study. About 240 patients with colorectal cancer were studied, they were diagnosed in the Pathology Department of the Cuenca Cancer Institute and who had their biopsy material where the immunohistochemical techniques were performed with 4 markers MLH1, MSH2, MSH6, and PMS2.

Results:

The 37.9% corresponded to men and 62.1% to women. The average age was 66.2 years. The 58.75% (n = 141) had localization in the colon. A lack of protein expression was observed in 24.2% (58 patients). Regarding to proteins, 68.96% (40 cases) were MLH1 / PMS2; 1.72% (1 case) MSH2 / MSH6. About the cases that did not express the proteins, 87.93% were located in the colon; 79.3% were adenocarcinoma; 58.6% were moderate grade and 37.9% were stage II. In the bivariate analysis, a statistically significant association was established between microsatellite instability with tumor location (OR 7.4, CI 3.2-17) and degree of differentiation (OR 2.8, CI 1.5-5.4).

Conclusions:

The protocolized use is recommended within the treatment of colorectal cancer.

Key words: colonic neoplasms, Microsatellite Instability, Prognosis.

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Published

2018-06-15

Issue

Vol. 36 No. 1 (2018): Revista de la Facultad de Ciencias Médicas de la Universidad de Cuenca

Section

Original Article

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