Queratoquiste odontogénico: ¿tumor o quiste? Revisión de la literatura
DOI:
https://doi.org/10.18537/fouc.v02.n02.a02Palabras clave:
queratoquiste odontogénico, tumor, quiste, patched (PTCH), proliferación celular, marcadores molecularesResumen
El queratoquiste odontogénico (OKC), descrito inicialmente como un quiste de desarrollo originado de la lámina dental o sus remanentes, ha experimentado cambios en su terminología y clasificación debido a variaciones clínicas y descubrimientos genéticos. Aunque se propuso como una neoplasia benigna en 1967, evidencia reciente lo clasifica nuevamente como queratoquiste odontogénico en la edición de la OMS de 2017. El objetivo de este análisis es evaluar la evidencia actual sobre el OKC considerando aspectos radiográficos, clínicos, histopatológicos y moleculares para determinar su naturaleza. Se revisaron 19 artículos obtenidos de bases de datos como PubMed, Scopus, SciELO y ScienceDirect, los cuales abordaron características como recurrencia, manifestaciones clínicas, hallazgos radiográficos, actualizaciones de la OMS, influencia genética, expresión de marcadores y comparaciones con otros quistes o tumores odontogénicos. Los hallazgos sugieren que el OKC es una patología incierta, ya que la controversia sobre su clasificación como quiste o neoplasia permanece sin resolución definitiva.
Descargas
Citas
Nishanth MS, Vishwas L, Gaurav. Odontogenic keratocyst-identity unearthed: A systematic review. Acta Scientific Dental Sciences. 2021;5(6):00–00. Available from: http://dx.doi.org/10.31080/ASDS.2021.05.
Bava EJ, Ortolani A, Pantyrer M. Queratoquiste odontogénico múltiple en un paciente pediátrico. Rev Asoc Odontol Argent. 2018;106(1):35–40. Available from: https://raoa.aoa.org.ar/revistas?roi=1061000052
Palacios-Álvarez I, González-Sarmiento R, Fernández-López E. Síndrome de Gorlin. Actas Dermosifiliogr. 2018;109(3):207–17. Available from: http://dx.doi.org/10.1016/j.ad.2017.07.018
Balandrano AGP. Queratoquiste odontogénico: Reporte de un caso y revisión de la literatura. Odonto Unam. 2019;23(1):00–00.
Campos J, Cavalcante I, Santos H. Recurrence rate of odontogenic keratocysts: Clinicalradiographic characterization throughout a 48-year period. Rev Port Estomatol Med Dent Cir Maxilofac. 2020;61(2):00–00. Available from: http://doi.org/10.24873/j.rpemd.2020.09.704
Gurkan U, Cicciù M, Saleh RA, Hammamy MA, Kadri AA, Kuran B, et al. Radiological evaluation of odontogenic keratocysts in patients with nevoid basal cell carcinoma syndrome: A review. Saudi Dent J. 2023;35(6):614–24. Available from: https://doi.org/10.1016/j.sdentj.2023.05.023
Pylkkö J, Willberg J, Suominen A, Laine HK, Rautava J. Appearance and recurrence of odontogenic keratocysts. Clin Exp Dent Res.2023;9(5):894–8. Available from: http://dx.doi.org/10.1002/cre2.796
Marwa M, Ghazy S, Elshafei M, Afifi N, Gad H, Rasmy M. Odontogenic keratocyst: A review of histogenesis, classification, clinical presentation, genetic aspect, radiographic picture, histopathology, and treatment. Egypt J Histol. 2021;45(2):325–37. Available from: https://doi.org/10.21608/ejh.2021.58363.1419
Stoelinga PJW. The odontogenic keratocyst revisited. J Oral Maxillofac Surg. 2022;51(11):1420–3. Available from: https://doi.org/10.1016/j.ijom.2022.02.005
Bello IO. Pediatric odontogenic keratocyst and early diagnosis of Gorlin syndrome: Clinicopathological aids. Saudi Dent J. 2023;36(1):38–43. Available from: https://doi.org/10.1016/j.sdentj.2023.10.012
Liu Z, Liu J, Zhou Z, Zhang Q, Wu H, Zhai G, et al. Differential diagnosis of meloblastoma and odontogenic keratocyst by machine learning of panoramic radiographs. Int J Comput Assist Radiol Surg. 2021;16(3):415–22. Available from: https://doi.org/10.1007/s11548-021-02309-0
Kaneko N, Sameshima J, Kawano S, Chikui T, Mitsuyasu T, Chen H, et al. Comparison of computed tomography findings between odontogenic keratocyst and ameloblastoma in the mandible: Criteria for differential diagnosis. J Oral Maxillofac Surg Med Pathol. 2023;35(1):15–22. Available from: https://doi.org/10.1016/j.ajoms.2022.07.016
Bianco CBF, Sperandio FF, Hanemann JAC, Pereira AAC. New WHO odontogenic tumor classification: Impact on prevalence in a population. J Appl Oral Sci. 2019;28(1):00–00. Available from: https://doi.org/10.1590/1678-7757-2019-0067
Vered M, Wright JM. Update from the 5th edition of the World Health Organization classification of head and neck tumors: Odontogenic and maxillofacial bone tumours. Head Neck Pathol. 2022;16(1):63–75. Available from: http://dx.doi.org/10.1007/s12105-021-01404-7
Pereira I, Matos FR, Bernardino Í, Santana ITS, Vieira WA, Blumenberg C, et al. RANK, RANKL, and OPG in dentigerous cyst, odontogenic keratocyst, and ameloblastoma: A meta-analysis. Braz Dent J. 2021;32(1):16–25. Available from: https://doi.org/10.1590/0103-6440202103387
Kisielowski K, Drozdzowska B, Koszowski R, Rynkiewicz M, Szuta M, Rahnama M, et al. Immunoexpression of RANK, RANKL, and OPG in sporadic odontogenic keratocysts and their potential association with recurrence. Adv Clin Exp Med. 2021;30(3):301–7. Available from: https://doi.org/10.17219/acem/130907
Mahnaz J, Hamblin MR, Pournaghi-Azar F, Vakili Saatloo M, Kouhsoltani M, Vahed N. Ki-67 expression as a diagnostic biomarker in odontogenic cysts and tumors: A systematic review and meta-analysis. J Dent Res Dent Clin Dent Prospects. 2021;15(1):66–75. Available from: https://doi.org/10.34172/joddd.2021.012
Portes J, Cunha KSG, Silva LE, Silva AKF, Conde DE, Junior AS. Computerized evaluation of the immunoexpression of ki-67 protein in odontogenic keratocyst and dentigerous cyst. Head Neck Pathol. 2019;14(3):598–605. Available from: https://doi.org/10.1007/s12105-019-01077-3
Singh A, Jain A, Shetty DC, Rathore AS, Juneja S. Immunohistochemical expression of p53 and murine double minute 2 protein in odontogenic keratocyst versus variants of ameloblastoma. J Cancer Res. 2020;16(3):521–9. Available from: https://doi.org/10.4103/jcrt.jcrt_659_18
Aldahash F. Systematic review and meta-analysis of the expression of p53 in odontogenic lesions. J Oral Maxillofac Pathol. 2023;27(1):168–72. Available from: http://dx.doi.org/10.4103/jomfp.jomfp_58_22
Slusarenko Y, Stoelinga PJW, Grillo R, Naclério-Homem MG. Cyst or tumor? A systematic review and meta-analysis on the expresión of p53 marker in odontogenic keratocysts. J Craniomaxillofac Surg. 2021;49(12):1101–6. Available from: https://doi.org/10.1016/j.jcms.2021.09.015
Stojanov JI, Inga SM, Menon RS, Wasman J, Gokozan HN, Garcia EP, et al. Biallelic PTCH1 inactivation is a dominant genomic change in sporadic keratocystic odontogenic tumors. Am J Surg Pathol. 2020;44(4):553– 60. Available from: http://doi/10.1097/PAS.0000000000001407
Hoyos A, Kaminagakura E, Rodrigues MFSD, Pinto CAL, Teshima THN, Alves FA. Immunohistochemical evaluation of Sonic Hedgehog signaling pathway proteins (Shh, Ptch1, Ptch2, Smo, Gli1, Gli2, and Gli3) in sporadic and syndromic odontogenic keratocysts. Clin Oral Investig. 2018;23(1):153–9. Available from: https://doi.org/10.1007/s00784-018-2421-2
Descargas
Publicado
Cómo citar
Número
Sección
Licencia
Derechos de autor 2024 Revista de la Facultad de Odontología de la Universidad de Cuenca
Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-CompartirIgual 4.0.
