Odontogenic keratocyst: Tumor or cyst? Literature review
DOI:
https://doi.org/10.18537/fouc.v02.n02.a02Keywords:
odontogenic keratocyst, tumor, cyst, patched (PTCH), cell proliferation, molecular markersAbstract
The odontogenic keratocyst (OKC), initially described as a developmental cyst originating from the dental lamina or its remnants, has undergone changes in terminology and classification due to clinical variations and genetic discoveries. Although it was proposed as a benign neoplasm in 1967, recent evidence reclassifies it as an odontogenic keratocyst in the 2017 WHO edition. This analysis aims to evaluate current evidence on OKC, considering radiographic, clinical, histopathological, and molecular aspects to determine its nature. A total of 19 articles from databases such as
PubMed, Scopus, SciELO, and ScienceDirect were reviewed, addressing features such as recurrence, clinical characteristics, radiographic findings, WHO updates, genetic influence, marker expression, and comparisons with other odontogenic cysts or
tumors. Findings suggest that OKC is an uncertain pathology, as the controversy over its classification as a cyst or neoplasm remains unresolved.
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